Search results for "Hand joint"
showing 4 items of 4 documents
Allelic variants of IL1R1gene associate with severe hand osteoarthritis
2010
Background In search for genes predisposing to osteoarthritis (OA), several genome wide scans have provided evidence for linkage on 2q. In this study we targeted a 470 kb region on 2q11.2 presenting the locus with most evidence for linkage to severe OA of distal interphalangeal joints (DIP) in our genome wide scan families. Methods We genotyped 32 single nucleotide polymorphisms (SNPs) in this 470 kb region comprising six genes belonging to the interleukin 1 superfamily and monitored for association with individual SNPs and SNP haplotypes among severe familial hand OA cases (material extended from our previous linkage study; n = 134), unrelated end-stage bilateral primary knee OA cases (n =…
Articulation du trapèze avec le second métacarpien : étude anatomique et intérêts cliniques
2008
Resume Introduction Confrontes a une association inedite de luxations etagees de la colonne du pouce et d’une fracture de la base du deuxieme metacarpien, les auteurs presentent une etude cadaverique de l’articulation trapezosecond metacarpien. Materiels et methodes Trente dissections de pieces formolees (15 mains droites et 15 mains gauches) et 15 pieces fraiches (huit mains droites et sept mains gauches), soit au total 45 dissections, ont permis d’observer les liens articulaires, ligamentaires et tendineux entre le trapeze et la base du deuxieme metacarpien en se focalisant sur les structures palmaires. Resultats L’articulation entre le trapeze et le deuxieme metacarpien a ete constamment…
Guidelines for the conduct of pharmacological clinical trials in hand osteoarthritis: Consensus of a Working Group of the European Society on Clinica…
2017
Objectives To gather expert opinion on the conduct of clinical trials that will facilitate regulatory review and approval of appropriate efficacious pharmacological treatments for hand osteoarthritis (OA), an area of high unmet clinical need. Methods The European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal diseases (ESCEO) organized a working group under the auspices of the International Osteoporosis Foundation (IOF) and the World Health Organization (WHO). Results This consensus guideline is intended to provide a reference tool for practice, and should allow for better standardization of the conduct of clinical trials in hand OA. Hand OA is …
Burned to the Bone
2017
A burn-related injury that had worsened over time was compatible upon radioclinical examination with severe psoriatic arthritis (PsA), but was missing several essential characteristics of that disorder. A 58-year-old woman with no personal or family history of rheumatic diseases consulted for hand arthralgia. Her medical history was marked by severe burns to 80% of her body, sparing the face and the back, following a gas explosion 20 years earlier. …